Well, I am mostly converted over. There are a couple of apps I use that don’t have Intel/Universal binaries yet. One is X-Chat Aqua and the other is eSVN. Both are ports of *nix applications. X-Chat is a full port to Cocoa. eSVN uses the QT toolkit.
The other frustration was fink. My PPC coworker uses it daily. I am not so lucky yet. Gentoo’s packages are for PPC also.
MySQL has presented a challenge as well. We are still using 4.0 on our servers. There are some backwards compatibility issues that are keeping us at 4.0. MySQL has a nice Mac package. But, because 4.0 is not a current release, they only offer PPC binaries. So, I will have to build it myself to get 4.0. I have been working around the problems for now and using 4.1. Maybe this is a good time to bite the bullet and change our code to support 4.1+.